Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness

Follow-up of Mild Papilledema in Idiopathic Intracranial Hypertension with Optical Coherence Tomography [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]

Simple Eye Test Measures Damage From Multiple Sclerosis

Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis

Retinal nerve fiber layer thickness is associated with lesion length in acute optic neuritis

RNFL thickness in MS-associated acute optic neuritis using SD-OCT: critical interpretation and limitations

Natural History of Leber's Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography

Automated Segmentation of Neural Canal Opening and Optic Cup in 3-D Spectral Optical Coherence Tomography Volumes of the Optic Nerve Head.

Associations between retinal nerve fiber layer abnormalities and optic nerve examination

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Articles in category: Neuro-Ophthalmology

1. Ability and Reproducibility of Fourier-Domain Optical Coherence Tomography to Detect Retinal Nerve Fiber Layer Atrophy in Parkinson's Disease Explore OphSource (Jun 28 2012) Journal Articles , Neuro-Ophthalmology Purpose: To evaluate and compare the ability of 3 protocols of Fourier-domain optical coherence tomography (OCT) to detect retinal thinning and retinal nerve fiber layer (RNFL) atrophy in patients with Parkinson's disease (PD) compared with healthy subjects. To test the intrasession reproducibility of RNFL thickness measurements in patients with ... (Read Full Article)

   Comment Mentions:   Cirrus HD-OCT

2. Color vision is strongly associated with retinal thinning in multiple sclerosis Explore Multiple Sclerosis (Jun 27 2012) Journal Articles , Neuro-Ophthalmology Objectives: Multiple Sclerosis (MS) frequently causes injury to the anterior visual pathway (AVP), impairing quality of life due to visual dysfunction. Development of biomarkers in MS is a high priority and both low-contrast visual acuity (LCVA) and time-domain optical coherence tomography (TD-OCT) have been proposed as candidates for this purpose ... (Read Full Article)

   Comment Mentions:   Carl Zeiss Meditec   Stratus OCT

3. Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis Explore OphSource (Feb 23 2012) Journal Articles , Neuro-Ophthalmology Purpose: We used high-resolution spectral-domain optical coherence tomography (SD-OCT) with retinal segmentation to determine how ganglion cell loss relates to history of acute optic neuritis (ON), retinal nerve fiber layer (RNFL) thinning, visual function, and vision-related quality of life (QOL) in multiple sclerosis (MS).Design: Cross-sectional study.Participants: A convenience ... (Read Full Article)

   Comment Mentions:   Schuman, Joel MD   University of Pittsburgh

4. Relationships among Multifocal Electroretinogram Amplitude, Visual Field Sensitivity, and SD-OCT Receptor Layer Thicknesses in Patients with Retinitis Pigmentosa Explore iovs.org (Feb 21 2012) Journal Articles , AMD , Neuro-Ophthalmology Purpose. To compare local functional measures, the multifocal electroretinogram (mfERG) and visual field sensitivity, with a local structural measure, spectral domain (SD) optical coherence tomography (OCT), of receptor damage in patients with retinitis pigmentosa (RP). Methods. MfERGs, visual fields, and SD-OCT scans were obtained from 10 patients with RP, ranging ... (Read Full Article)

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5. Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness Explore Multiple Sclerosis (Nov 30 2011) Journal Articles , Neuro-Ophthalmology Background: Post-mortem analyses of multiple sclerosis (MS) eyes demonstrate prominent retinal neuronal ganglion cell layer (GCL) loss, in addition to related axonal retinal nerve fiber layer (RNFL) loss. Despite this, clinical correlations of retinal neuronal layers remain largely unexplored in MS. Objectives: To determine if MS patients exhibit in vivo ... (Read Full Article)

   Comment Mentions:   Cirrus HD-OCT

6. Recent advances in optic neuritis related to multiple sclerosis Explore Wiley Online Library (Apr 12 2011) Journal Articles , Neuro-Ophthalmology More advanced methods of detecting and quantifying optic neuritis (ON) in multiple sclerosis have been developed in the past 15 years. This review focuses on developments in optical coherence tomography (OCT) measurement of the retinal nerve fibre layer (RNFL) and its role in monitoring axonal loss in the course of ... (Read Full Article)

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7. RNFL thickness in MS-associated acute optic neuritis using SD-OCT: critical interpretation and limitations Explore Wiley Online Library (Mar 15 2011) Journal Articles , Glaucoma , Neuro-Ophthalmology Axonal loss is considered a key prognostic factor in diagnosing and monitoring the progress of multiple sclerosis (MS). The purpose of our research was to determine whether the measurement of retinal nerve fibre layer thickness (RNFLT) as measured with high-resolution spectral-domain optical coherence tomography (SD-OCT) differs between optic nerve injury ... (Read Full Article)

   Comment Mentions:   Medical University of Vienna

8. Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis Explore Nature Publishing Group (Dec 24 2010) Journal Articles , Neuro-Ophthalmology Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis (Read Full Article)

   Comment Mentions:   Cirrus HD-OCT   Stratus OCT

9. Interpretation of RNFLT values in multiple sclerosis-associated acute optic neuritis using high-resolution SD-OCT device Explore Wiley Online Library (Nov 1 2010) Journal Articles , Neuro-Ophthalmology Optical coherence tomography (OCT) has emerged as the technique of choice in measuring the retinal nerve fibre layer (RNFL) quantitatively. It is suggested that RNFL reduction may correlate with lesion burden and diffuse axonal degeneration in the whole CNS of patients with multiple sclerosis (MS). However, RNFL changes because of ... (Read Full Article)

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10. Associations between retinal nerve fiber layer abnormalities and optic nerve examination Explore Neurology (Oct 11 2010) Journal Articles , Neuro-Ophthalmology Retinal nerve fiber layer (RNFL) abnormalities detected by optical coherence tomography (OCT) are useful markers for axonal loss and visual dysfunction in multiple sclerosis (MS), but their role in routine clinical management is not well-studied. (Read Full Article)

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11. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis. Lauren S. Talman. 2010; Annals of Neurology - Wiley InterScience Explore www3.interscience.wiley.com (Jul 21 2010) Neuro-Ophthalmology Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes ... (Read Full Article)

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12. Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity -- Balcer and Frohman 74 (173): S16 -- Neurology Explore Neurology (Jul 21 2010) Neuro-Ophthalmology Because these impairments are often not readily apparent on commonly used high-contrast acuity tests, low-contrast charts (e.g., low-contrast Sloan letter charts) have gained validity in the assessment of visual dysfunction in patients with MS. (Read Full Article)

    Comment Mentions:   Laura J. Balcer

13. Comparison of Optical Coherence Tomography and Scanning Lase... : Optometry & Vision Science Explore LWW Online (Jul 21 2010) Neuro-Ophthalmology To compare optical coherence tomography (OCT) and scanning laser polarimetry (GDx) measurements of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis (ON). (Read Full Article)

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14. Arch Neurol -- Abstract: Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis, July 2008, Zaveri et al. 65 (7): 924 Explore Archives of Neurology, a monthly peer (Jul 21 2010) Neuro-Ophthalmology Scanning laser polarimetry with variable corneal compensation measurements of RNFL thickness corroborates OCT evidence of visual pathway axonal loss in MS and provides new insight into structural aspects of axonal loss that relate to RNFL birefringence (microtubule integrity). These results support validity for RNFL thickness as a marker for axonal ... (Read Full Article)

    Comment Mentions:   Laura J. Balcer

15. Automated Segmentation of Neural Canal Opening and Optic Cup in 3-D Spectral Optical Coherence Tomography Volumes of the Optic Nerve Head. Explore NCBI HomePage (Jul 12 2010) Neuro-Ophthalmology To develop an automated approach for segmenting the neural canal opening (NCO) and cup at the level of retinal pigment epithelium (RPE)/Bruch's membrane (BM) complex in spectral-domain optical coherence tomography (SD-OCT) volumes. (Read Full Article)

    Comment Mentions:   Cirrus HD-OCT

16. Time domain and spectral domain optical coherence tomography in multiple sclerosis: A comparative cross-sectional study Explore Multiple Sclerosis (Jul 12 2010) Neuro-Ophthalmology Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. (Read Full Article)

    Comment Mentions:   Carl Zeiss Meditec   Cirrus HD-OCT   Stratus OCT

17. Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients Explore ScienceDirect (Jul 12 2010) Neuro-Ophthalmology RNFLT reduction across all four quadrants in MS patients as a whole as well as in MS/NON eyes argues for a diffuse neurodegenerative process. (Read Full Article)

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18. Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis. Explore NCBI HomePage (Jul 12 2010) Neuro-Ophthalmology Scanning laser polarimetry with variable corneal compensation measurements of RNFL thickness corroborates OCT evidence of visual pathway axonal loss in MS and provides new insight into structural aspects of axonal loss that relate to RNFL birefringence (microtubule integrity). (Read Full Article)

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19. Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study Explore Multiple Sclerosis (Jul 9 2010) Journal Articles , Neuro-Ophthalmology Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has ... (Read Full Article)

    Comment Mentions:   Carl Zeiss Meditec   Cirrus HD-OCT   Stratus OCT

20. Reproducibility of high-resolution optical coherence tomography in multiple sclerosis Explore Multiple Sclerosis (Jul 9 2010) Journal Articles , Neuro-Ophthalmology Optical coherence tomography (OCT) is a non-invasive method to quantify neurodegeneration as an outcome in multiple sclerosis clinical trials; however, no data exist on Cirrus spectral domain optical coherence tomography (SD-OCT) reproducibility in patients with multiple sclerosis. The objective of this study was to determine the protocol for achieving optimal ... (Read Full Article)

    Comment Mentions:   Cirrus HD-OCT

21. Simple Eye Test Measures Damage From Multiple Sclerosis Explore Medical News Today (Jun 8 2010) News , Neuro-Ophthalmology A quick, painless eye measurement shows promise as a way to diagnose multiple sclerosis in its very early stages, and to track the effectiveness of treatments, researchers from UT Southwestern Medical Center have found in a multicenter study... (Read Full Article)

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22. Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry Explore SpringerLink Home (May 12 2010) Journal Articles , Neuro-Ophthalmology The objectives of this study are (1) to compare OCT with the GDx ECC; (2) to assess and compare the RNFL thickness in subgroups of MS. (Read Full Article)

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23. Correlation between macular and retinal nerve fibre layer Fourier-domain OCT measurements and visual field loss in chiasmal compression Explore Nature Publishing Group (Apr 30 2010) Journal Articles , Neuro-Ophthalmology , Retina The aim of this study was to test the correlation between Fourier-domain (optical coherence tomography macular and retinal nerve fibre layer thickness and visual field loss on standard automated perimetry in chiasmal compression. (Read Full Article)

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24. Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis [Visual Neurophysiology] Explore iovs.org (Apr 29 2010) Journal Articles , Neuro-Ophthalmology This study demonstrated structural–functional discrepancy during the process of recovery from acute optic neuritis. (Read Full Article)

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