Articles from iovs.org

1. Glaucoma Detection Ability of Ganglion Cell-Inner Plexiform Layer Thickness by Spectral-Domain Optical Coherence Tomography in High Myopia Explore iovs.org (Mar 28 2013) Journal Articles Purpose. To compare the glaucoma detection ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with Cirrus spectral-domain optical coherence tomography (SD-OCT) with that of peripapillary retinal nerve fiber layer (RNFL) thickness in high myopia. Methods. In 49 highly myopic and 54 nonhighly myopic glaucoma patients—along with 78 ... (Read Full Article)

   Comment Mentions:   Cirrus HD-OCT

2. Progressive Loss of Retinal Ganglion Cell Function Precedes Structural Loss by Several Years in Glaucoma Suspects Explore iovs.org (Mar 28 2013) Journal Articles Purpose. We determined the time lag between loss of retinal ganglion cell function and retinal nerve fiber layer (RNFL) thickness. Methods. Glaucoma suspects were followed for at least four years. Patients underwent pattern electroretinography (PERG), optical coherence tomography (OCT) of the RNFL, and standard automated perimetry testing at 6-month intervals ... (Read Full Article)

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3. Relating Retinal Nerve Fiber Layer Thickness and Functional Estimates of Ganglion Cell Sampling Density in Healthy Eyes and in Early Glaucoma Explore iovs.org (Mar 27 2013) Journal Articles Purpose. To investigate the relationship between retinal nerve fiber layer (RNFL) thickness and peripheral grating resolution acuity (PGRA) as well as differential light sensitivity (DLS) in healthy subjects and patients with early glaucoma. The agreement between estimates of retinal ganglion cell (GC) density from each functional test is explored. Methods ... (Read Full Article)

   Comment Mentions:   Stratus OCT

4. Enhancement of Lamina Cribrosa Visibility in Optical Coherence Tomography Images Using Adaptive Compensation Explore iovs.org (Mar 27 2013) Journal Articles Purpose. We improved the visibility of the lamina cribrosa (LC), including its posterior boundary, in optical coherence tomography (OCT) images of the human optic nerve head (ONH). Methods. An adaptive compensation algorithm was developed to overcome a limitation of our standard compensation algorithm, that is the overamplification of noise at ... (Read Full Article)

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5. Choroidal Thickness in Fellow Eyes of Patients with Acute Primary Angle-Closure Measured by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography Explore iovs.org (Mar 19 2013) Journal Articles Purpose. We evaluated choroidal thickness in the fellow eyes of patients with acute primary angle-closure (APAC) and compared findings to those of normal controls. Methods. The study group comprised 44 fellow eyes defined as primary angle-closure suspect (PACS) of 44 subjects who had experienced APAC and 43 eyes of 43 ... (Read Full Article)

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6. Microstructure of Parapapillary Atrophy: Beta Zone and Gamma Zone Explore iovs.org (Mar 19 2013) Journal Articles Purpose. To examine the morphologic features of parapapillary atrophy by using enhanced depth imaging optical coherence tomography (EDI-OCT) and color fundus photographs. Methods. The clinical observational comparative study included 80 normal eyes of 46 subjects and 80 eyes of 46 patients with primary open-angle glaucoma. Both groups did not vary ... (Read Full Article)

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7. Usefulness of Macular Thickness Derived from Spectral-Domain Optical Coherence Tomography in the Detection of Glaucoma Progression Explore iovs.org (Mar 15 2013) Journal Articles Purpose. To assess the reproducibility of circumpapillary retinal nerve fiber layer thickness (cRNFLT) and total macular thickness (TMT) parameters using Cirrus spectral domain optical coherence tomography (SD-OCT) and to apply this information to investigate its ability to detect cases where visual field (VF) progression was noted on event-based analysis in ... (Read Full Article)

   Comment Mentions:   Cirrus HD-OCT

8. Influence of the Eye-Tracking-Based Follow-Up Function in Retinal Nerve Fiber Layer Thickness Using Fourier-Domain Optical Coherence Tomography Explore iovs.org (Mar 15 2013) Journal Articles Purpose. To evaluate the eye-tracking–based follow-up (EBF) function in the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained with Fourier-domain optical coherence tomography (Fd-OCT). Methods. Thirty healthy subjects were imaged on an Fd-OCT device at the same visit by two examiners. Peripapillary circular scans in ... (Read Full Article)

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9. Modulation of Transgene Expression in Retinal Gene Therapy by Selective Laser Treatment Explore iovs.org (Mar 13 2013) Journal Articles Purpose. To develop a method for modulation of transgene expression in retinal pigment epithelium (RPE) using scanning laser that spares neurosensory retina. Methods. Fifteen pigmented rabbits received subretinal injection of recombinant adeno-associated virus (rAAV-2) encoding green fluorescent protein (GFP). GFP expression was measured using confocal scanning laser ophthalmoscopy (cSLO) fluorescence ... (Read Full Article)

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10. Semiautomated Segmentation of the Choroid in Spectral-Domain Optical Coherence Tomography Volume Scans Explore iovs.org (Mar 7 2013) Journal Articles Purpose. Changes in the choroid, in particular its thickness, are believed to be of importance in the pathophysiology of a number of retinal diseases. The purpose of this study was to adapt the graph search algorithm to semiautomatically identify the choroidal layer in spectral-domain optical coherence tomography (SD-OCT) volume scans ... (Read Full Article)

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11. Relationship between Intraocular Pressure and Angle Configuration: An Anterior Segment OCT Study Explore iovs.org (Mar 5 2013) Journal Articles Purpose. To assess the relationship between intraocular pressure (IOP) and anterior chamber angle (ACA) configuration as assessed by gonioscopy and anterior segment optical coherence tomography (AS-OCT). Methods. A total of 2045 subjects aged 50 years and older, were recruited from a community clinic and underwent AS-OCT, Goldmann applanation tonometry, and ... (Read Full Article)

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12. Abnormal Thickening as well as Thinning of the Photoreceptor Layer in Intermediate Age-Related Macular Degeneration Explore iovs.org (Mar 5 2013) Journal Articles Purpose. To investigate the relationship between photoreceptor layers overlying and adjacent to large drusen in intermediate nonneovascular AMD. Methods. Patients with AMD (n = 41; aged 53–83 years) and elderly control subjects without eye disease (n = 10; aged 51–79 years) were studied with spectral-domain optical coherence tomography. Characteristics of ... (Read Full Article)

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13. Keratoconus Diagnosis Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography Explore iovs.org (Feb 19 2013) Journal Articles Purpose. To investigate the tissue properties of keratoconic and normal corneas in vivo by using polarization-sensitive optical coherence tomography (PS-OCT), and to evaluate early keratoconus by the area under the receiver operating characteristic curve (AUROC) and Mahalanobis distance analysis. Methods. Thirty-one eyes of 20 patients with keratoconus, 7 eyes of ... (Read Full Article)

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14. The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities Explore iovs.org (Feb 19 2013) Journal Articles Purpose. To compare the sensitivity of volume scanning with optical coherence tomography (OCT) to nonmydriatic color fundus photography (FP) for the detection of retinal irregularities in asymptomatic populations. Methods. Asymptomatic subjects without known ocular disease were recruited over a 6-month period. For each eye, two undilated 45° fundus images and ... (Read Full Article)

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15. Correlations between Spectral-Domain OCT Measurements and Visual Acuity in Cystoid Macular Edema Associated with Retinitis Pigmentosa Explore iovs.org (Feb 13 2013) Journal Articles Purpose. To evaluate the characteristics of spectral-domain optical coherence tomography (SD-OCT) findings associated with visual outcome and compare OCT measurements according to presence of cystoid macular edema (CME) in retinitis pigmentosa (RP) patients. Methods. Patients with typical RP who underwent SD-OCT were included. We compared OCT measurements such as central ... (Read Full Article)

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16. Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants Using Optical Coherence Tomography Explore iovs.org (Feb 13 2013) Journal Articles Purpose. To use three-dimensional optical coherence tomography (3D-OCT) to assess the prevalence of juxtapapillary retinal pigment epithelial detachments (jPED) in an asymptomatic population. Methods. Asymptomatic participants (i.e., family members of patients) were prospectively recruited over a 6-month period. Each subject completed a questionnaire prior to the acquisition of two ... (Read Full Article)

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17. The Relationship between Foveal Ischemia and Spectral-Domain Optical Coherence Tomography Findings in Ischemic Diabetic Macular Edema Explore iovs.org (Feb 7 2013) Journal Articles Purpose. To investigate the relationship between enlargement of the foveal avascular zone (FAZ) and structural changes on spectral-domain optical coherence tomography (SD-OCT) in patients with ischemic diabetic macular edema (DME). Methods. This was a retrospective, cross-sectional study including 35 eyes of 33 patients with ischemic DME as determined by irregular ... (Read Full Article)

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18. Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography Explore iovs.org (Feb 7 2013) Journal Articles Purpose. To determine the effect of travoprost 0.004% on Schlemm's canal (SC) in healthy human eyes using Fourier-domain optical coherence tomography (FD-OCT). Methods. Twelve healthy volunteers were recruited for a double-blind, placebo-controlled, randomized, and paired comparison study. Right eyes of subjects were randomly assigned to receive either travoprost ... (Read Full Article)

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19. High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability Explore iovs.org (Jan 30 2013) Journal Articles Purpose. To develop and test a novel signal enhancement method for optical coherence tomography (OCT) images based on the high dynamic range (HDR) imaging concept. Methods. Three virtual channels, which represent low, medium, and high signal components, were produced for each OCT signal dataset. The dynamic range of each signal ... (Read Full Article)

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20. A Hierarchical Cluster Analysis of Primary Angle Closure Classification Using Anterior Segment Optical Coherence Tomography Parameters Explore iovs.org (Jan 30 2013) Journal Articles Purpose. To investigate the possibility of classifying angle closure eyes in terms of features provided by anterior segment optical coherence tomography (AS OCT). Methods. Angle closure (primary angle closure [PAC] or PAC glaucoma [PACG]) eyes diagnosed by gonioscopy were imaged using AS OCT under the same lighting conditions. Anterior chamber ... (Read Full Article)

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21. Lesion Size Detection in Geographic Atrophy by Polarization-Sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques Explore iovs.org (Jan 28 2013) Journal Articles Purpose. To investigate the reproducibility of automated lesion size detection in patients with geographic atrophy (GA) using polarization-sensitive spectral-domain optical coherence tomography (PS-OCT) and to compare findings with scanning laser ophthalmoscopy (SLO), fundus autofluorescence (FAF), and intensity-based spectral-domain OCT (SD-OCT). Methods. Twenty-nine eyes of 22 patients with GA were examined ... (Read Full Article)

    Comment Mentions:   Cirrus HD-OCT

22. The Role of Axial Resolution of Optical Coherence Tomography on the Measurement of Corneal and Epithelial Thicknesses [Multidisciplinary Ophthalmic Imaging] Explore iovs.org (Jan 28 2013) Journal Articles Purpose. Our purpose was to investigate the role of the axial resolution of optical coherence tomography (OCT) on the measurement of corneal and epithelial thickness by evaluating the repeatability and agreement among different OCT devices with different axial resolutions. Methods. Twenty right eyes of 20 healthy subjects (age: 22.3 ... (Read Full Article)

    Comment Mentions:   Visante omni

23. Variations in Iris Volume with Physiologic Mydriasis in Subtypes of Primary Angle Closure Glaucoma Explore iovs.org (Jan 23 2013) Journal Articles Purpose. To compare the changes in iris volume with pupil dilation using anterior segment optical coherence tomography (AS-OCT) in eyes of subjects with different subtypes of primary angle closure. Methods. This prospective study examined 44 fellow eyes (FA group) of subjects with previous acute primary angle closure (APAC), and 56 ... (Read Full Article)

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24. Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging Explore iovs.org (Jan 17 2013) Journal Articles Purpose. We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). Methods. The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber layer (RNFL) thickness ... (Read Full Article)

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