Articles from Neurology

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    1. Fingolimod treatment in multiple sclerosis leads to increased macular volume

      Explore Neurology (Jan 7 2013) Journal Articles

      Objective: To determine whether fingolimod, an oral sphingosine-1-phosphate receptor modulator approved for treatment of multiple sclerosis (MS), generally leads to increased retinal tissue volume. Methods: In this longitudinal observational study, we compared changes in macular volume on spectral-domain optical coherence tomography (OCT) between consecutive patients with MS who initiated fingolimod ...

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      Mentions:   National Institute of Health

    2. Sex-specific differences in retinal nerve fiber layer thinning after acute optic neuritis

      Explore Neurology (Oct 29 2012) Journal Articles

      Objective: The primary objective of this study was to explore the potential influence of gender on recovery from optic neuritis (ON) by determining whether differences in retinal nerve fiber layer (RNFL) thickness can be detected between men and women 6 months after an ON event. Methods: In this prospective cohort ...

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      Mentions:   National Institute of Health

    3. Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

      Explore Neurology (Aug 15 2011) Journal Articles , Retina

      Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve ... (Read Full Article)

    4. Associations between retinal nerve fiber layer abnormalities and optic nerve examination

      Explore Neurology (Oct 11 2010) Journal Articles , Neuro-Ophthalmology

      Retinal nerve fiber layer (RNFL) abnormalities detected by optical coherence tomography (OCT) are useful markers for axonal loss and visual dysfunction in multiple sclerosis (MS), but their role in routine clinical management is not well-studied. (Read Full Article)

    5. Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity -- Balcer and Frohman 74 (173): S16 -- Neurology

      Explore Neurology (Jul 21 2010) Neuro-Ophthalmology

      Because these impairments are often not readily apparent on commonly used high-contrast acuity tests, low-contrast charts (e.g., low-contrast Sloan letter charts) have gained validity in the assessment of visual dysfunction in patients with MS. (Read Full Article)

      Mentions:   Laura J. Balcer

    6. Retinal nerve fiber layer thickness is associated with lesion length in acute optic neuritis

      Explore Neurology (Jan 18 2010) Journal Articles , Neuro-Ophthalmology

      In this study of the acute phase of optic neuritis, the degree of optic nerve head edema depended upon the extent of the optic nerve lesion, but not on its location. This suggests that factors other than inflammation, such as compromised venous drainage, vascular leakage, impaired axonal transport, and other ... (Read Full Article)

    7. Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

      Explore Neurology (Jul 26 2009) Journal Articles

      Neurology: Optical coherence tomography (OCT) shows more severe retinal damage after optic neuritis (ON) episodes in neuromyelitis optica (NMO) than in relapsing–remitting multiple sclerosis. (Read Full Article)

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